| Identification | Back Directory | [Name]
1,2-PROPANEDIOL-D8 | [CAS]
80156-55-4 | [Synonyms]
1,2-PROPANEDIOL-D8
propylene glycol-d8
1,2-PROPANEDIOL-D8, 98 ATOM % D
1,2-Propanediol-d8
Discontinued, see P760312 | [Molecular Formula]
C3D8O2 | [MDL Number]
MFCD00142484 | [MOL File]
80156-55-4.mol | [Molecular Weight]
84.14 |
| Chemical Properties | Back Directory | [Melting point ]
-60 °C (lit.) | [Boiling point ]
187 °C (lit.) | [density ]
1.143 g/mL at 25 °C | [refractive index ]
n20/D 1.432(lit.) | [Fp ]
225 °F | [InChI]
1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/i1D3,2D2,3D,4D,5D | [InChIKey]
DNIAPMSPPWPWGF-INOGVRQUSA-N | [SMILES]
[2H]OC([2H])([2H])C([2H])(O[2H])C([2H])([2H])[2H] | [CAS Number Unlabeled]
57-55-6 |
| Hazard Information | Back Directory | [Uses]
(±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents[1][2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] De Cock RF, et al. Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Ther Drug Monit. 2014 Jun;36(3):278-87. DOI:10.1097/FTD.0000000000000003 |
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