| Identification | Back Directory | [Name]
CTEP Derivative | [CAS]
802906-73-6 | [Synonyms]
RG7090
RG-7090
RG 7090
RO 491752)
Ro 4917523
BasiMglurant
CTEP Derivative
RG7090(Basimglurant)
Basimglurant sulfate (RG 7090
BASIMGLURANT; RG 7090; RG-7090; CTEP DERIVATIVE
2-Chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl)ethynyl)pyridine
2-Chloro-4-[2-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl]ethynyl]pyridine
Pyridine, 2-chloro-4-[2-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl]ethynyl]- | [Molecular Formula]
C18H13ClFN3 | [MDL Number]
MFCD25976719 | [MOL File]
802906-73-6.mol | [Molecular Weight]
325.77 |
| Chemical Properties | Back Directory | [Melting point ]
132 - 135°C | [Boiling point ]
526.6±60.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
5.27±0.70(Predicted) | [color ]
Pale Brown to Light Brown | [Stability:]
Hygroscopic, Moisture Sensitive | [InChI]
InChI=1S/C18H13ClFN3/c1-12-17(8-3-14-9-10-21-18(19)11-14)22-13(2)23(12)16-6-4-15(20)5-7-16/h4-7,9-11H,1-2H3 | [InChIKey]
UPZWINBEAHDTLA-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=CC(C#CC2=C(C)N(C3=CC=C(F)C=C3)C(C)=N2)=C1 |
| Hazard Information | Back Directory | [Uses]
Basimglurant is a potent, selective and orally available mGlu5 negative allosteric modulator for the treatment of mood disorders. | [in vivo]
Basimglurant (RG7090) is a potent, selective, and safe mGlu5 inhibitor with good oral bioavailability and long half-life supportive of once-daily administration, good brain penetration, and high in vivo potency. It has antidepressant properties which are corroborated by its functional magnetic imaging (fMRI) profile, as well as anxiolytic-like and antinociceptive features[1]. It is currently in phase II clinical studies for the treatment of depression and fragile X syndrome. In the Vogel conflict drinking test, Basimglurant dose dependently increases the drinking time. The total plasma exposure of efficacious doses of Basimglurant (RG7090) ranges from 5 ng/mL (0.03 mg/kg) to 37 ng/mL (0.3 mg/kg)[2]. | [IC 50]
mGlu5 Receptor: 1.1 nM (Kd) |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|