| Identification | Back Directory | [Name]
Silybin | [CAS]
802918-57-6 | [Synonyms]
Silybin A,B (Mixture)
Silybin (Mixture of Diastereomers)
4H-1-Benzopyran-4-one, 2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- | [EINECS(EC#)]
806-403-5 | [Molecular Formula]
C25H22O10 | [MOL File]
802918-57-6.mol | [Molecular Weight]
482.44 |
| Chemical Properties | Back Directory | [Melting point ]
152-153°C | [Boiling point ]
793.0±60.0 °C(Predicted) | [density ]
1.527±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Acetone (Sparingly, Sonicated, Heated), DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
7.39±0.60(Predicted) | [color ]
Pale Yellow to Beige | [InChIKey]
SEBFKMXJBCUCAI-DBMPWETRSA-N | [SMILES]
[C@H]1(C2=CC=C3OC(CO)C(C4=CC=C(O)C(OC)=C4)OC3=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O |
| Hazard Information | Back Directory | [Chemical Properties]
Beige Solid | [Uses]
Hepatoprotectant. In nature, the flavonolignan Silybin occurs as a mixture of two diastereomers, Silybin A and Silybin B. | [General Description]
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate. | [in vivo]
Silybin (50, 100?mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].
| Animal Model: | Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)[2] | | Dosage: | 50, 100?mg/kg | | Administration: | Given intragastrically; daily; for the last 4 weeks | | Result: | Significantly lowered both serum and hepatic lipid accumulation.
|
| [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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