| Identification | Back Directory | [Name]
C4, HUMAN | [CAS]
80295-48-3 | [Synonyms]
C4, HUMAN
COMPLEMENT C4
COMPLEMENT C4, HUMAN
COMPLEMENT C4 FROM HUMAN SERUM | [MDL Number]
MFCD00130838 |
| Hazard Information | Back Directory | [Uses]
Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples. | [General Description]
Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein. | [Biochem/physiol Actions]
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia. |
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