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Mouse complement C5a is a 77-amino acid peptide generated during complement activation from the α-chain of complement C5. Mouse C5a shares 60% and 82% amino acid sequence identity to human and rat C5a, respectively. The 9 kDa mouse C5a protein expressed in E. coli contains a N-terminal His-Tag sequence. | [Biological Activity]
C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88)inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophilsand induces release of histamine in basophils and mast cells. |
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