| Identification | More | [Name]
4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE | [CAS]
80745-07-9 | [Synonyms]
4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE
4-METHOXY-2,3,6-TRIMETHYLBENZENESULPHONYL CHLORIDE
4-METHOXY-2,3,6-TRIMETHYLPHENYLSULFONYL CHLORIDE
MTR CHLORIDE
MTR-CL
4-METHOXY-2,3,6-TRIMETHYLBENZENE-
Benzenesulfonyl chloride, 4-methoxy-2,3,6-trimethyl-(9CI)
4-Methoxy-2,3,6-trimethylphenylaulfomyl chloride
4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE: TECH., 90%
4-METHOXY-2,3,6-TRIMETHYLBENZENE-SULFONYL CHLORIDE 97+% | [EINECS(EC#)]
626-430-4 | [Molecular Formula]
C10H13ClO3S | [MDL Number]
MFCD00038846 | [Molecular Weight]
248.73 | [MOL File]
80745-07-9.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3261 8/PG 3
| [WGK Germany ]
3
| [F ]
3-10-21 | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29093090 |
| Hazard Information | Back Directory | [Uses]
peptide synthesis | [Synthesis]
(2) Synthesis of 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride: 4.5 g of 2,3,5-trimethylanisole was dissolved in 500 mL of dichloromethane and the reaction system was cooled to -5 °C to -10 °C. The reaction system was then cooled to -5 °C to -10 °C. The reaction system was then cooled to -5 °C to -10 °C. Subsequently, 6.0 mL of a dichloromethane solution of chlorosulfonic acid (400 mL) was added slowly and dropwise. After completion of the reaction mixture with stirring at room temperature, the reaction was quenched by pouring it into an ice-5% aqueous NaHCO3 solution. The organic phase was separated and the aqueous phase was extracted with dichloromethane. The organic layers were combined, washed with water and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was recrystallized by hexane and filtered to give white crystals. Yield 5.0 g (yield 67.0%), melting point 56°C-58°C. Elemental analysis (C10H13O3SCl) Calculated values: C, 48.29; H, 5.27; S, 12.89; Cl, 14.26; Measured values: C, 48.42; H, 5.21; S, 12.61; Cl, 14.25. | [References]
[1] Chemical & Pharmaceutical Bulletin, 1981, vol. 29, # 10, p. 2825 - 2831
[2] Tetrahedron Letters, 2007, vol. 48, # 8, p. 1337 - 1340
[3] Patent: US4368150, 1983, A
[4] Patent: US4476051, 1984, A |
|
|