| Identification | Back Directory | [Name]
TELENZEPINE 2HCL | [CAS]
80880-90-6 | [Synonyms]
SK-871
Telenzepine
TELENZEPINE 2HCL
telenzepine dihydrochloride hydrate
1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one
10H-Thieno[3,4-b][1,5]benzodiazepin-10-one, 4,9-dihydro-3-methyl-4-[2-(4-methyl-1-piperazinyl)acetyl]-
4,9-dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10h-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrobromide | [Molecular Formula]
C19H22N4O2S | [MDL Number]
MFCD00083208 | [MOL File]
80880-90-6.mol | [Molecular Weight]
370.475 |
| Chemical Properties | Back Directory | [Melting point ]
263-264° | [Boiling point ]
544.7±50.0 °C(Predicted) | [density ]
1.281±0.06 g/cm3(Predicted) | [solubility ]
H2O: >10 mg/mL | [form ]
solid | [pka]
12.48±0.20(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM)[1]. | [Definition]
ChEBI: 1-methyl-10-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one is a benzodiazepine. | [References]
[1] Telenzepine. IMGT. DOI:10.1016/0014-2999(89)90741-3 |
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