| Identification | More | [Name]
4-Methyl-1-piperazineethanamine | [CAS]
934-98-5 | [Synonyms]
1-(2-AMINOETHYL)-4-METHYL-PIPERAZINE
1-(N-AMINOETHYL)-4-METHYL PIPERAZINE
2-(4-METHYLPIPERAZIN-1-YL)ETHANAMINE
2-(4-METHYL-PIPERAZIN-1-YL)-ETHYLAMINE
4-METHYL-1-PIPERAZINEETHANAMINE
AKOS BB-6128
CHEMBRDG-BB 4006383
4-methylpiperazine-1-ethylamine
1-(2-AMINOETHYL)METHYLPIPERAZINE
2-(4-Methyl-piperazin-1-yl)-ethylamine ,98%
1-Methyl-4-(2-aminoethyl)piperazine | [EINECS(EC#)]
213-296-3 | [Molecular Formula]
C7H17N3 | [MDL Number]
MFCD03701701 | [Molecular Weight]
143.23 | [MOL File]
934-98-5.mol |
| Chemical Properties | Back Directory | [Boiling point ]
103°C/11.25mm | [density ]
0.956±0.06 g/cm3(Predicted) | [refractive index ]
1.4780 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
liquid | [pka]
10.11±0.10(Predicted) | [color ]
Colourless to light yellow | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR,MS | [InChI]
InChI=1S/C7H17N3/c1-9-4-6-10(3-2-8)7-5-9/h2-8H2,1H3 | [InChIKey]
GOWUDHPKGOIDIX-UHFFFAOYSA-N | [SMILES]
N1(CCN)CCN(C)CC1 | [CAS DataBase Reference]
934-98-5(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2735 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid | [Definition]
ChEBI: A N-alkylpiperazine that is piperazine substituted by a methyl and a 2-aminoethyl group at the N atoms respectively. | [Synthesis]
Step 5. To a stirred suspension of lithium aluminum hydride (3.3 g, 87 mmol) in anhydrous THF (100 mL) was slowly added a solution of 2-(4-methylpiperazin-1-yl)acetonitrile (11.2 g, 80.4 mmol) in anhydrous THF (300 mL) at 0 °C. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the mixture was cooled in an ice bath and H2O (3.3 mL) and 20% NaOH solution (3.3 mL) were added sequentially. After stirring for 20 minutes, the mixture was filtered and the solvent was evaporated. The residue was dissolved in ethyl acetate and dried with anhydrous sodium sulfate. The solvent was evaporated to dryness to give 2-(4-methylpiperazin-1-yl)ethylamine as an oil (1.15 g, 99%).1H NMR (400 MHz, CDCl3) δ: 2.21 (s, 3H), 2.20-2.60 (m, 10H), 2.71 (t, J=6.0 Hz, 2H). | [References]
[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 15, p. 2870 - 2880
[2] Patent: WO2013/148365, 2013, A1. Location in patent: Paragraph 0086
[3] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 7, p. 2251 - 2259
[4] Patent: WO2016/16728, 2016, A2. Location in patent: Paragraph 000703; 000704
[5] Patent: WO2005/35532, 2005, A1. Location in patent: Page/Page column 30 |
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