| Identification | More | [Name]
COUMACHLOR | [CAS]
81-82-3 | [Synonyms]
3-[1-(4-CHLOROPHENYL)-3-OXOBUTYL]-4-HYDROXYCOUMARIN
3-(α-acetonyl-4-chlorobenzyl)-4-hydroxycoumarin
3-(ALPHA-ACETONYL-4-CHLOROBENZYL)-4-HYDROXYCOUMARIN
(+/-)-3-(ALPHA-ACETONYL-P-CHLOROBENZYL)-4-HYDROXYCOUMARIN
COUMACHLOR
DL-3-(ALPHA-ACETONYL-4'-CHLOROBENZYL)-4-HYDROXYCOUMARIN
FAMARIN
P-CHLOROWARFARIN
3-(1-(4-chloorfenyl)-3-oxo-butyl)-4-hydroxy-cumarine
3-(1-(4-chlorophenyl)-3-oxobutyl)-4-hydroxy-2h-1-benzopyran-2-on
3-(1-(4-chlorophenyl)-3-oxo-butyl)-4-hydroxy-coumarine
3-(1-(4-chlor-phenyl)-3-oxo-butyl)-4-hydroxy-cumarin
3-(1-(4-cloro-fenil)-3-oxo-butil)-4-idrossicumarina
3-(1-acetyl-2-(p-chlorophenyl)ethyl)-4-hydroxycoumarin
3-(alpha-(p-chlorphenyl)-beta-acetylaethyl)-4-hydroxycumarin
3-(alpha-acetonyl-p-chlorobenzyl)-4-hydroxy-coumari
3-(alpha-p-chlorophenyl-beta-acetylethyl)-4-hydroxycoumarin
4-hydroxy-3-(1-(4-chlorophenyl)-3-oxobutyl)-2h-1-benzopyran-2-one
coumachlore
cumachloor | [EINECS(EC#)]
201-378-1 | [Molecular Formula]
C19H15ClO4 | [MDL Number]
MFCD00012094 | [Molecular Weight]
342.77 | [MOL File]
81-82-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
168-170 °C (lit.) | [Boiling point ]
543.1±50.0 °C(Predicted) | [density ]
1.2972 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
acetone: soluble | [form ]
powder
| [pka]
4.50±1.00(Predicted) | [color ]
light yellow
| [Merck ]
13,2581 | [BRN ]
6819431 | [InChI]
1S/C19H15ClO4/c1-11(21)10-15(12-6-8-13(20)9-7-12)17-18(22)14-4-2-3-5-16(14)24-19(17)23/h2-9,15,22H,10H2,1H3 | [InChIKey]
DEKWZWCFHUABHE-UHFFFAOYSA-N | [SMILES]
CC(=O)CC(c1ccc(Cl)cc1)C2=C(O)c3ccccc3OC2=O | [CAS DataBase Reference]
81-82-3(CAS DataBase Reference) | [EPA Substance Registry System]
Coumachlor (81-82-3) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed .
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S37:Wear suitable gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2811 6.1/PG 1
| [WGK Germany ]
2
| [RTECS ]
GN4830000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 1 Dermal
Acute Tox. 3 Oral
Aquatic Chronic 3
STOT RE 2 | [Hazardous Substances Data]
81-82-3(Hazardous Substances Data) | [Toxicity]
MLD in dog, swine (mg/kg): <5, <5 orally (Wanntorp) |
| Hazard Information | Back Directory | [Description]
Coumachlor is a first generation rodenticide which is now largely obsolete. There are many gaps in the available data, however, it has a low aqueous solubility and is not volatile. It is highly toxic to birds and aquatic invertebrates. It also has a high oral toxicity to mammals. | [Chemical Properties]
White to Off-White Solid | [Uses]
Coumachlor was used as internal standard for simultaneous enantioseparation of (+/-)-warfarin by chiral capillary electrochromatography with electrospray ionization mass spectrometry. | [Uses]
An internal standard in the analysis of the rodenticide Warfarin. | [Uses]
Rodenticide. | [Definition]
ChEBI: Coumachlor is a hydroxycoumarin. | [Production Methods]
Coumachlor is commercially produced through a multi-step organic synthesis process. The key reaction involves the condensation of 4-hydroxycoumarin with 4-chlorobenzylacetone under controlled conditions to form the final compound: 3-[1-(4-chlorophenyl)-3-oxobutyl]-2-hydroxychromen-4-one. This synthesis typically takes place in the presence of a base and a solvent such as ethanol or acetic acid, followed by purification steps including crystallisation and drying. | [General Description]
Coumachlor is an anticoagulant rodenticide. It forms complex with zirconium. | [Mechanism of action]
1st generation anticoagulant, blocks formation of prothrombin, inhibits blood coagulation causing death by internal haemorrhage | [Pesticide Type]
Rodenticide |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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China Langchem Inc.
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0086-21-58956006 |
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www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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Maya High Purity Chemicals
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+86 (573) 82222445 (0)18006601000 452520369 |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
SIMAGCHEM CORP
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http://www.simagchem.com/ |
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