| Identification | Back Directory | [Name]
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 | [CAS]
81039-85-2 | [Synonyms]
pro(4)-trp(7,9)-substancep(4-11
Substance P, [D-Pro4, D-Trp7,9]
substance P (4-11), Pro(4)-Trp(7,9)-
(D-PRO4,D-TRP7,9)-SUBSTANCE P (4-11)
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
H-D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
[D-PRO4,D-TRP7,9]-SUBSTANCE P (4-11) ACOH 4H2O
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 ACOH 4H2O
DPRO-GLN-GLN-DTRP-PHE-DTRP-LEU-MET-NH2: DP-QQ-DW-F-DW-LM-NH2
D-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2
L-Methioninamide, D-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl- (9CI) | [Molecular Formula]
C57H75N13O10S | [MDL Number]
MFCD00076810 | [MOL File]
81039-85-2.mol | [Molecular Weight]
1134.35 |
| Hazard Information | Back Directory | [Uses]
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1]. | [in vivo]
[D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea[1].
[D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells[2]. | [References]
[1] Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. DOI:10.1016/0014-2999(82)90561-1
[2] Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8. DOI:10.1016/0143-4179(95)90056-x |
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