| Identification | Back Directory | [Name]
Mal-PEG1-t-butyl ester | [CAS]
810677-16-8 | [Synonyms]
Mal-PEG1-Boc
Mal-PEG1-t-butyl ester
Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H19NO5 | [MDL Number]
MFCD28142478 | [MOL File]
810677-16-8.mol | [Molecular Weight]
269.29 |
| Hazard Information | Back Directory | [Description]
Mal-PEG1-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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