| Identification | Back Directory | [Name]
Mal-PEG3-NHS ester | [CAS]
1537892-36-6 | [Synonyms]
Mal-PEG3-NHS
Mal-PEG3-NHS ester
2,5-Dioxo-1-pyrrolidinyl 3-[2-[2-[2-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]ethoxy]ethoxy]propanoate
Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C17H22N2O9 | [MDL Number]
MFCD26127782 | [MOL File]
1537892-36-6.mol | [Molecular Weight]
398.36 |
| Chemical Properties | Back Directory | [Boiling point ]
552.4±60.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DCM | [form ]
Liquid | [pka]
-2.34±0.20(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Mal-PEG3-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-PEG3-NHS ester is a noncleavable ADC linker containing a Maleimide group. Mal-PEG3-NHS ester is used for making antibody-drug conjugate[1]. | [IC 50]
Non-cleavable Linker | [References]
[1] Gautam S, et al. Immobilization of hydrophobic peptidic ligands to hydrophilic chromatographic matrix: a preconcentration approach. Anal Biochem. 2012 Apr 15;423(2):202-9. DOI:10.1016/j.ab.2012.01.020 |
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