| Identification | Back Directory | [Name]
Momordicoside G | [CAS]
81371-54-2 | [Synonyms]
Momordicoside G
Momordicacoside G
Momordica charantia saponin G
β-D-Allopyranoside, (3S,5R,8S,9S,10S,13R,14S,17R)-1,3,4,8,10,11,12,13,14,15,16,17-dodecahydro-17-[(1R,3E)-5-methoxy-1,5-dimethyl-3-hexenyl]-4,4,13,14-tetramethyl-5,9-(epoxymethano)-2H-cyclopenta[a]phenanthren-3-yl | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C37H60O8 | [MDL Number]
MFCD20260922 | [MOL File]
81371-54-2.mol | [Molecular Weight]
632.88 |
| Chemical Properties | Back Directory | [Boiling point ]
711.4±60.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
12.91±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Momordicoside G can be used to regulate macrophage phenotypes to stimulate lung injury repair, as well as, prevent urethane-induced lung carcinoma lesions. It can also be used for anti-diabetic and anti-inflammatory effects. | [Definition]
ChEBI: Momordicoside G is a glycoside and a cucurbitacin. | [in vivo]
Lung carcinogenic model in ICR mice is induced by Urethane (HY-B1207) (600 mg/kg; i.p.; once weekly for 4 or 8 weeks), or in in macrophage-competent and macrophage-deleted mice is induced by LPS (HY-D1056) (2 mg/kg; intratracheal method) with 4 mg/mouse IEC (i.p.)[1].
Momordicoside G (50 mg/kg; p.o.; once daily for 4 or 8 weeks) prevents urethane-induced lung injury and carcinoma lesions in mouse lung carcinogenic model[1].
Momordicoside G (50 mg/kg; p.o.; once daily for 2 weeks) promotes lung injury repair in LPS-induced lung injury model[1].
| Animal Model: | Mouse lung carcinogenic model: Urethane-induced lung carcinogenic model and LPS-induced lung injury model[1] | | Dosage: | 50 mg/kg | | Administration: | Oral gavage; once daily for 4 or 8 weeks | | Result: | Affected inflammasome and cytokines during urethane-induced lung injury and carcinoma lesions.
Exhibits macrophage-regulating capacity in LPS-induced lung injury model. |
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