ChemicalBook--->CAS DataBase List--->81525-10-2

81525-10-2

81525-10-2 Structure

81525-10-2 Structure
IdentificationBack Directory
[Name]

NAFAMOSTAT MESYLATE
[CAS]

81525-10-2
[Synonyms]

FUTHAN
FUT-175
Nafamstat
NAFAMOSTAT
NAFAMOSTAT MESILATE
Mesylate nafaMostat
NafamostatMesilateBase
Nafamostat Dimethanesulfonate
6-Amidino-2-naphthyl 4-guanidinobenzoate
6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE, MESYLATE
4-Guanidinobenzoic acid 6-amidino-2-naphtyl ester
4-(Amidinoamino)benzoic acid 6-amidino-2-naphtyl ester
6-AMIDINO-2-NAPHTHYL-4-GUANIDINOBENZOATE DIMETHANESULFONATE
Benzoic acid, 4-[(aMinoiMinoMethyl)aMino]-, 6-(aMinoiMinoMethyl)-2-naphthalenyl ester
[EINECS(EC#)]

1806241-263-5
[Molecular Formula]

C21H25N5O8S2
[MDL Number]

MFCD00941430
[MOL File]

81525-10-2.mol
[Molecular Weight]

539.58
Chemical PropertiesBack Directory
[Boiling point ]

586.0±60.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[pka]

11.30±0.30(Predicted)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

6-Bromo-2-naphthol-->6-Cyano-2-naphthol-->4-carbamimidamidobenzoic acid
Hazard InformationBack Directory
[Chemical Properties]

Odorless, bitter taste. Easily soluble in water, insoluble in methanol, ethanol or dimethylformamide, almost insoluble in ether, chloroform or acetone. Density: 1.39g/cm3; Boiling Point: 637.2°C; Flash Point: 339.1°C; Vapor Pressure: 3.9E-16mmHg.
[Uses]

Nafamostat is a non-peptide synthetic protease inhibitor with broad-spectrum and potent enzyme inhibition. For the treatment of acute pancreatitis. It can improve acute symptoms of acute pancreatitis, acute exacerbation of chronic pancreatitis, and post-traumatic pancreatitis.
[Definition]

ChEBI: Nafamostat is a member of benzoic acids and a member of guanidines.
[Preparation]

6-Bromo-2-naphthol reacts with copper cyanide in dimethylformamide to generate 6-cyano-2-naphthol, which is methanolylated and then aminolyzed to generate 6-amidino-2-naphthol , and finally esterification with p-guanidinobenzoic acid to generate nafamostat.
[storage]

Store at -20°C
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