| Identification | More | [Name]
Acipimox | [CAS]
51037-30-0 | [Synonyms]
5-methylpyrazine-2-carboxylic acid 4-oxide
ACIPIMOX
5-methyl-2-pyrazinecarboxylicaci4-oxide
5-methyl-2-pyrazinecarboxylicacid4-oxide
4-Oxo-5-Methyl-2-Pyrazine-carboxylic Acid
4-Oxide-5-Methylpyrazine-2-CarboxylicAcid
5-METHYLPYRAZINECARBOXYLICACID4-OXIDE
5-METHYLPYRANZINECARBOXYLIC ACID 4-OXIDE
2-Carboxy-5-methylpyrazine 4-oxide, 5-Methylpyrazinecarboxylic acid 4-oxide
K-9321
Olbemox
Olbetam
5-Carboxy-2-methylpyrazine 1-oxide
Acipimox (5-Methylpyrazinecarboxylic acid 4-oxide) | [EINECS(EC#)]
256-928-3 | [Molecular Formula]
C6H6N2O3 | [MDL Number]
MFCD00865757 | [Molecular Weight]
154.12 | [MOL File]
51037-30-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RTECS ]
UQ2453000 |
| Questions And Answer | Back Directory | [Description]
Acipimox is a potent long-acting antilipolytic nicotinic acid (NA) analog. Like nicotinic acid, acipimox lowers lipids effectively, but unlike nicotinic acid, acipimox is longer acting and therefore much less prone to produce free fatty acid rebounding.
Acipimox is recommended as a lipid-lowering agent to treat hyperlipidemia in patients with noninsulin dependent diabetes mellitus.
| [References]
[1] Ana T.M.G. Santomauro, Guenther Boden, Maria E.R. Silva, Dalva M. Rocha, Rosa F. Santos, Mileni J.M. Ursich, Paula G. Strassmann and Bernardo L. Wajchenberg, Overnight Lowering of Free Fatty Acids With Acipimox Improves Insulin Resistance and Glucose Tolerance in Obese Diabetic and Nondiabetic Subjects, Diabetes, 1999, vol. 48, 1836-1841
[2] K. C. Shih, C. F. Kwok, C. M. Hwu, L. C. Hsiao, S. H. Li, Y. F. Liu, L. T. Ho, Acipimox attenuates hypertriglyceridemia in dyslipidemic noninsulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control, Diabetes Research and Clinical Practice, 1997, vol. 36, 113-119
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