| Identification | More | [Name]
Bambuterol hydrochloride | [CAS]
81732-46-9 | [Synonyms]
BAMBEC
BAMBUTEROL HCL
BAMBUTEROL HYDROCHLORIDE
dimethylcarbamic acid 5-[2[(1,1-dimethyl)amino]1-hydroxyethyl]-1,3-phenylene ester hydrochloride
DIMETHYLCARBAMIC ACID 5-[2-[(1,1-DIMETHYLETHYL)AMINO]-1-HYDROXYETHYL]-1,3-PHENYLENE ESTER HYDROCHLORIDE
KWD-2183
Bambuterol monohydrochloride
BAMBUTEROL HYDROCHLORIDE, EP STANDARD
Dimethylcarbamic Acid 5-[2-(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene Ester, Hydrochloride, KWD-2183, Bambec,
Dimethylcarbmic acid 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester | [EINECS(EC#)]
643-060-9 | [Molecular Formula]
C18H30ClN3O5 | [MDL Number]
MFCD03427293 | [Molecular Weight]
403.9 | [MOL File]
81732-46-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
222-224°C | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
H2O: ~33 mg/mL, soluble
| [form ]
powder
| [color ]
off-white
| [Usage]
Ester prodrug of the ?-adrenergic agonist terbutaline | [Merck ]
14,953 | [InChIKey]
LBARATORRVNNQM-UHFFFAOYSA-N | [CAS DataBase Reference]
81732-46-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Bambuterol is an inactive prodrug of terbutaline. It has a prolonged duration
of action when administered orally. | [Chemical Properties]
White Solid | [Uses]
beta adrenergic agonist, bronchodilator, cholinesterase inhibitor | [Uses]
Ester prodrug of the ?2-adrenergic agonist terbutaline. | [Uses]
Ester prodrug of the ?-adrenergic agonist terbutaline | [Definition]
ChEBI: The hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | [Synthesis]
Conventionally, as a method for preparing bambuterol hydrochloride, bis-3,5- (N, N-dimethylcarba) is subjected to an acylation process from 3 ′, 5′-dihydroxyacetophenone represented by the following reaction formula in US Pat. No. 4419364. Preparing moyloxy) -acetophenone (step 1); Preparing a bis-3 ′, 5 ′-(N, N-dimethylcarbamoyloxy) -2-bromo-acetophenone therefrom (step 2); Preparing an bis-3 ′, 5 ′-(N, N-dimethylcarbamoyloxy) -2- (N-benzyl tert-butyl) amino-acetophenone from the alkylation process therefrom (step 3); From this step to prepare a 1- [bis- (3 ', 5'-N, N-dimethylcarbamoyloxy) phenyl] -2-N-3 tert-butylaminoethanol hydrochloride, ie bambuterol hydrochloride.
 | [storage]
Store at -20°C |
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