| Identification | More | [Name]
2,3-DIFLUORO-6-NITROPHENOL | [CAS]
82419-26-9 | [Synonyms]
2,3-DIFLUORO-6-NITROPHENOL
2-HYDROXY-3,4-DIFLUORO NITROBENZENE
6-NITRO-2,3-DIFLUOROPHENOL
2,3-Didluoro-6-nitrophenol
2,3-Difluoro-6-Nitrophenol98%
2,3-Difluoro-6-nitrophenol, 97+%
Difluoro-6-nitrophenol
2,3-Difluoro-6-nitrophenol 97% | [Molecular Formula]
C6H3F2NO3 | [MDL Number]
MFCD00042255 | [Molecular Weight]
175.09 | [MOL File]
82419-26-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
60-62 °C (lit.) | [Boiling point ]
215.9±35.0 °C(Predicted) | [density ]
1.5200 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
4.77±0.37(Predicted) | [color ]
White to Light yellow to Green | [BRN ]
4410368 | [CAS DataBase Reference]
82419-26-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Toxic | [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [HS Code ]
29089990 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow crystals | [Uses]
2,3-Difluoro-6-nitrophenol was used in the synthesis of 2-methyl-6,7-difluoro-8-oxyquinoline. | [Synthesis]
a. Add 45.2 g of 2,3,4-trifluoronitrobenzene and 99.5 g of dimethyl sulfoxide (DMSO) to a 1000 mL three-necked flask and stir until completely dissolved. b. Adjust the temperature of the reaction system to 15~17°C, slowly add 125 g of 32% potassium hydroxide (KOH) solution dropwise, and strictly control the temperature during the dropwise addition process. c. Continue to stir the reaction for 3 hours at 15~17°C. d. Upon completion of the reaction, cool the reaction system to 14~16°C, slowly add 290 g of 7.6% potassium hydroxide. e. Add 290 g of 7.6% hydrochloric acid, and slowly add 290 g of 7.6% hydrochloric acid, and stir for 3 hours. -nitrophenol. | [References]
[1] Patent: US5292967, 1994, A
[2] Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 12, p. 4907 - 4913
[3] Patent: US4382892, 1983, A
[4] Patent: CN106632444, 2017, A. Location in patent: Paragraph 0032; 0033; 0034; 0035; 0036; 0037; 0038-0041 |
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