| Identification | Back Directory | [Name]
2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE | [CAS]
83-98-7 | [Synonyms]
C07935
WS 2434
Disipal
Biorphen
Orphenadine
Orphenadrin
Orphenedrine
orphenadrine
AURORA KA-7797
Ophenadrinecitrate
Orphenadrine-d3 HCl
ORPHEDRINE FREE BASE
Orphenadrine USP/EP/BP
Orphenadrine free base
O-METHYLDIPHENHYDRAMINE
2-Methyldiphenhydramine
ORPHENADRINE RELATED COMPOUND C
2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE
Orphenadrine (base and/or unspecified salts)
2-dimethylaminoethyl 2-methylbenzhydryl ether
PHENYL-O-TOLYLMETHYL DIMETHYLAMINOETHYL ETHER
B-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER
beta-Dimethylaminoethyl-2-methylbenzhydryl ether
N,N-Dimethyl-2-[(2-methyl-α-phenylbenzyl)oxy]ethanamine
N,N-Dimethyl-2-[(o-methyl-α-phenylbenzyl)oxy]ethanamine
N,N-Dimethyl-2-[[α-(2-methylphenyl)benzyl]oxy]ethylamine
N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine
Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-
Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-
OrphenadrineQ: What is
Orphenadrine Q: What is the CAS Number of
Orphenadrine Q: What is the storage condition of
Orphenadrine | [EINECS(EC#)]
201-509-2 | [Molecular Formula]
C18H23NO | [MDL Number]
MFCD00053670 | [MOL File]
83-98-7.mol | [Molecular Weight]
269.38 |
| Chemical Properties | Back Directory | [Melting point ]
25°C | [Boiling point ]
bp12 195° | [density ]
1.0278 (rough estimate) | [refractive index ]
1.5740 (estimate) | [form ]
Solid | [pka]
pKa 8.4 (Uncertain) | [color ]
Light yellow to brown | [Water Solubility ]
1.801mg/L(22.5 ºC) | [CAS DataBase Reference]
83-98-7 |
| Hazard Information | Back Directory | [Originator]
Norflex,Riker,US,1959 | [Uses]
Relaxant (skeletal muscle); antihistaminic. | [Definition]
ChEBI: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol. | [Manufacturing Process]
As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid. | [Brand name]
Norflex (3M Pharmaceuticals). | [Therapeutic Function]
Muscle relaxant | [Enzyme inhibitor]
This muscle relaxant and antihistaminic agent (FWfree-base = 269.39 g/mol;
CAS 83-98-7) is both a muscarinic and histamine H1 receptor antagonist
that also inhibits some cytochrome P450 systems. Classified as an
anticholinergic drug (with 58% as potent as atropine) and an ethanolamine-
class antihistamine, it also inhibits the noradrenergic transporter and
NMDA receptor ion channel (Ki ≈ 6 μM). Commercially available as either
the hydrochloride or citrate salt, orphenadrines used to relieve pain of
muscle injuries, such as strains and sprains. Target (s) : aldehyde oxidase
; CYP1A2; CYP2A6; CYP3A4; CYP2B; CYP2B6
; CYP2C9; CYP2C19; CYP2D6; histamine H1 receptor
; N-methyl-D-aspartate (NMDA) receptor; muscarinic receptor
; noradrenaline reuptake. |
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