| Identification | Back Directory | [Name]
CYCLOPIAZONIC ACID | [CAS]
83136-88-3 | [Synonyms]
CPA
CYCLOPIAZONIC ACID
PENICILLIUM CYCLOPIUM
ALPHA CYCLOPIAZONIC ACID
CYCLOPIAZONIC ACID, PENICILLIUM CYCLOPIUM
(6AR,11AS,11BR)-REL-10-ACETYL-2,6,6A,7,11A,11B-HEXAHYDRO-7,7-DIMETHYL-9H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-9-ONE
6H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indole-9,11(2H,7H)-dione, 6a,10,11a,11b-tetrahydro-10-(1-hydroxyethylidene)-7,7-dimethyl-, (6aR,10Z,11aS,11bR)-
(6AA, 10Z, 11AB, 11BA)-6A,7,11A,11B-TETRAHYDRO-10-(1-HYDROXYETHYLIDENE)-7,7- DIMETHYL-6H-PYRROLO [1',2':2,3]ISOINDOLO [4,5,6-CD]INDOLE-9,11 (2H,10H)-DIONE | [EINECS(EC#)]
200-585-4 | [Molecular Formula]
C20H20N2O3 | [MDL Number]
MFCD00167445 | [MOL File]
83136-88-3.mol | [Molecular Weight]
336.38 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
36/37/39-45 | [RIDADR ]
UN 2811 6.1/PG 2 | [WGK Germany ]
3 | [RTECS ]
UY8587000 | [Toxicity]
Cyclopiazonic acid is a natural contaminant of
cheese, corn, and peanuts. Due to the lack of analytical methods
for quantifying cyclopiazonic acid, the amount present in
the food supply and the potential health risks are uncertain.
Cyclopiazonic acid distributes widely in mammalian tissues,
especially skeletal muscle, and produces equally diverse cytotoxicity.
This toxicant shares many pharmacological properties
with antipsychotic drugs including catalepsy, hypothermia,
hypokinesia, ptosis, tremor, gait disturbance, sedation without
loss of righting reflex, atypical convulsion, and increased barbiturate
sleeping time. The mode of action of cyclopiazonic
acid involves its role as an inhibitor of Ca-ATPase. |
| Hazard Information | Back Directory | [Uses]
Cyclopiazonic Acid is an inhibitor of endoplasmic reticulum Ca2+-ATPase. | [Definition]
ChEBI: Alpha-cyclopiazonic acid is a member of alpha-cyclopiazonic acids. It is a conjugate acid of an alpha-cyclopiazonate. It is a tautomer of a (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one. |
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