| Identification | Back Directory | [Name]
Bonducellin | [CAS]
83162-84-9 | [Synonyms]
Bonducellin
4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-3-[(4-methoxyphenyl)methylene]-, (3E)- | [Molecular Formula]
C17H14O4 | [MOL File]
83162-84-9.mol | [Molecular Weight]
282.29 |
| Chemical Properties | Back Directory | [Melting point ]
215-217 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) | [Boiling point ]
526.3±50.0 °C(Predicted) | [density ]
1.318±0.06 g/cm3(Predicted) | [pka]
7.58±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L)[1]. | [References]
[1] Roy SK, et al. 7-Hydroxy-(E)-3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc2 155. Eur J Med Chem. 2013 Aug;66:499-507. DOI:10.1016/j.ejmech.2013.06.024 |
|
| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
Aobolihui
|
| Tel: |
0917-18691729 18691729963 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList957491/0_EN.htm |
|