| Identification | Back Directory | [Name]
DELAPRIL | [CAS]
83435-66-9 | [Synonyms]
DELAPRIL
Alindapril
Delaprilum
Indalapril
Unii-W77ual9thi
Delaprilum [latin]
DELAPRIL USP/EP/BP
N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-N-(indan-2-yl)Gly-OH
N-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-N-(indan-2-yl)glycine
N-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-N-(indan-2-y1)glycine
Glycine, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)-
Glycine, N-(2,3-dihydro-1H-inden-2-yl)-N-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-, (S)-
[N-(Indan-2-yl)-N-[(S)-1-[(S)-3-phenyl-1-(ethoxycarbonyl)propylamino]ethylcarbonyl]amino]acetic acid
2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid | [Molecular Formula]
C26H32N2O5 | [MDL Number]
MFCD00865804 | [MOL File]
83435-66-9.mol | [Molecular Weight]
452.54 |
| Chemical Properties | Back Directory | [Boiling point ]
659.7±55.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O:0.005(Max Conc. mg/mL);0.01(Max Conc. mM) | [pka]
3.07±0.10(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
Delapril Hydrochloride: C26H32N2O5?HCl. [83435-67-0]. Obtained as colorless flaky crystals from acetone-hydrochloric acid, melting point 166-170°C (decomposition). [α]D22+18.5 (C=1, methanol). | [Uses]
Antihypertensive; enzyme inhibitor (angiotensinconverting). | [Definition]
ChEBI: Delapril is a peptide. | [in vivo]
Delapril (5-20 mg/kg, fed in drinking water) slows the progression of atherosclerosis in cholesterol-fed rabbits[2].
Delapril (1-10 mg/kg, p.o., daily for 5 weeks) shows antihypertensive effect spontaneously in hypertensive rats[3].
| Animal Model: | Cholesterol-fed rabbits[2] | | Dosage: | 5 mg/kg at D5, 10 mg/kg at D10, 20 mg/kg at D20 | | Administration: | Fed in a fixed volume (10 ml) of drinking water | | Result: | Decreased aortic area covered by lesions.
Restored endothelium-dependent relaxation
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| Company Name: |
LGM Pharma
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| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
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