834903-43-4

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834903-43-4 Structure

Identification	Back Directory
[Name] CID 16020046
[CAS] 834903-43-4
[Synonyms] CS-1189 C390-0219 CID 16020046 CID16020046 (CID 16020046) CID16020046;CID 16020046;CID 16020046 4-[4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-benzoic acid Benzoic acid, 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-
[Molecular Formula] C25H19N3O4
[MDL Number] MFCD06196075
[MOL File] 834903-43-4.mol
[Molecular Weight] 425.44

Chemical Properties	Back Directory
[Boiling point ] 748.1±60.0 °C(Predicted)
[density ] 1.425±0.06 g/cm3(Predicted)
[storage temp. ] 2-8°C
[solubility ] DMSO: soluble1mg/mL, clear (warmed)
[form ] powder
[pka] 4.27±0.10(Predicted)
[color ] white to beige
[InChI] InChI=1S/C25H19N3O4/c1-14-5-7-15(8-6-14)21-20-22(27-26-21)24(30)28(18-11-9-16(10-12-18)25(31)32)23(20)17-3-2-4-19(29)13-17/h2-13,23,29H,1H3,(H,26,27)(H,31,32)
[InChIKey] VGUQVYZXABOXCX-UHFFFAOYSA-N
[SMILES] C(O)(=O)C1=CC=C(N2C(C3=CC=CC(O)=C3)C3C(C4=CC=C(C)C=C4)=NNC=3C2=O)C=C1

Questions And Answer	Back Directory
[Uses] CID 16020046 is a selective GPR55 antagonist. It Inhibits LPI-induced Ca2+ signaling, ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. It displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. It decreases LPI-induced GPR55 internalization.

Hazard Information	Back Directory
[Biochem/physiol Actions] CID16020046 is a potent and a selective GPR55 antagonist that inhibits GPR55-mediated ERK1/2 phosphorylation. CID16020046 inhibits LPI-induced Ca2+ signaling in HEK-GPR55 cells.
[storage] Store at -20°C

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