| Identification | Back Directory | [Name]
SPQ | [CAS]
83907-40-8 | [Synonyms]
SPQ
SPQ, INNER SALT
3-(6-METHOXYQUINOLINE)PROPANESULFONATE
6-METHOXY-N-(3-SULFOPROPYL) QUINOLINIUM
3-(6-METHOXYQUINOLINO)PROPANE SULFONATE
6-Methoxy-1-(3-sulfopropyl)-quinolinium
1-(3-Sulfonatopropyl)-6-methoxyquinolinium
6-METHOXY-N-(3-SULFOPROPYL) QUINOLINIUM 98+%
3-(6-METHOXYQUINOLINIUM-1-YL)PROPANE-1-SULFONATE
6-Methoxy-1-(3-sulfopropyl)quinoliniuM Inner Salt
6-methoxy-1-(3-sulfopropyl)quinolinium monohydrate
6-methoxy-1-(3-sulfopropyl)chinolinium monohydrate
6-METHOXY-N-(3-SULFOPROPYL)QUINOLINIUM, INNER SALT
QUINOLINIUM, 6-METHOXY-1-(3-SULFOPROPYL)-, INNER SALT
6-Methoxy-1-(3-sulfopropyl)quinolinium monohydrate, SPQ
3-(6-Methoxyquinolinium-1-yl)-1-propanesulfonic acid anion
3-(6-Methoxy-1-quinolinio)propanesulfonate inner salt monohydrate
3-(6-Methoxy-1-quinolinio)propanesulfonate monohydrate inner salt | [Molecular Formula]
C13H15NO4S | [MDL Number]
MFCD00037592 | [MOL File]
83907-40-8.mol | [Molecular Weight]
281.33 |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Tan Cyrstalline Solid | [Melting point ]
299°C dec. | [storage temp. ]
-20°C Freezer | [solubility ]
Soluble in water, dimethyl sulfoxide | [form ]
powder | [color ]
White | [λmax]
344 nm | [Biological Applications]
Chloride indicator; nitrite indicator; diagnosis of diseases caused by elemental imbalances; detecting cancer cells,spores,stress biomarkers; identifying genes; studying chloride–bicarbonate exchange |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Tan Cyrstalline Solid | [Uses]
SPQ offers a simple and yet powerful method to examine and measure membrane chloride transport mechanisms. | [Description]
SPQ is a fluorescent chloride indicator. Its fluorescence is rapidly quenched by chloride in vitro. It has been used to assess voltage-sensitive chloride transport in placental microvillus vesicles. It has also been used to continuously quantify intracellular calcium efflux induced by parathyroid hormone, forskolin , and phorbol 12-myristate 13-acetate (PMA; ) in isolated human erythrocytes. In addition, SPQ has been used to determine the type of ion conductance induced by the cystic fibrosis transmembrane conductance regulator (CFTR) in HEK293 cells expressing pTrial10-CRTR2. SPQ displays excitation maxima of 320 and 350 nm and an emission maximum of 445 nm. | [References]
[1] NICHOLAS P. ILLSLEY Alan S V. Membrane chloride transport measured using a chloride-sensitive fluorescent probe[J]. Biochemistry Biochemistry, 1987, 26 5: 1215-1219. DOI: 10.1021/bi00379a002
[2] LAURA SOLDATI . Chloride Fluxes Activated by Parathyroid Hormone in Human Erythrocytes[J]. Biochemical and biophysical research communications, 2000, 269 2: Pages 470-473. DOI: 10.1006/bbrc.2000.2320
[3] L J MACVINISH. Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2.[J]. Journal of Physiology-London, 1997, 499 3: 677-687. DOI: 10.1113/jphysiol.1997.sp021960 |
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