| Identification | More | [Name]
3-Amino-1-propanesulfonic acid | [CAS]
3687-18-1 | [Synonyms]
3-AMINO-1-PROPANESULFONIC ACID
3-AMINOPROPANESULFONIC ACID
3 APS
HOMOTAURINE
aminopropanesulfonicacid,3-aminopropanesulfonicacid
3-aminopropane-1-sulphonic acid
TRAMIPROSATE
3-AMINOPROPANE-1-SULFONIC ACID
3-Aminopropiosulfonic Acid
3-Sulfopropylamine
Alzhemed
NC 758
NSC 77071
1-Propanesulfonic acid, 3-amino-
3-Aminopropan-1-sulfonsure | [EINECS(EC#)]
222-977-4 | [Molecular Formula]
C3H9NO3S | [MDL Number]
MFCD00008225 | [Molecular Weight]
139.17 | [MOL File]
3687-18-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White Powder | [Melting point ]
293 °C (dec.)(lit.)
| [density ]
1.202 (estimate) | [refractive index ]
1.5130 (estimate) | [storage temp. ]
Store at 0-5°C | [solubility ]
Water (Slightly) | [form ]
Crystalline Powder | [pka]
1.06±0.50(Predicted) | [color ]
White to slightly blue | [Usage]
Important gaba mimetic agent. It evokes neurological responses similar to those elicited by g-aminobutyric acid | [Cosmetics Ingredients Functions]
SURFACTANT - HYDROTROPE
SURFACTANT - CLEANSING | [InChI]
InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7) | [InChIKey]
SNKZJIOFVMKAOJ-UHFFFAOYSA-N | [SMILES]
C(S(O)(=O)=O)CCN | [LogP]
-4.555 | [CAS DataBase Reference]
3687-18-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN2585 | [WGK Germany ]
1
| [REACH Registrations]
Active | [HazardClass ]
8 | [HS Code ]
29049090 | [Storage Class]
13 - Non Combustible Solids |
| Hazard Information | Back Directory | [Description]
Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation.1 Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates.2 It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.3 | [Chemical Properties]
White Powder | [Uses]
Important gaba mimetic agent. It evokes neurological responses similar to those elicited by g-aminobutyric acid | [Definition]
ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid. | [Biological Activity]
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo . | [storage]
Store at -20°C | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ISMAEL SANTA-MARIA. Tramiprosate, a drug of potential interest for the treatment of Alzheimer’s disease, promotes an abnormal aggregation of tau.[J]. Molecular Neurodegeneration, 2007: 17. DOI: 10.1186/1750-1326-2-17
[3] A. GIOTTI. Homotaurine: a GABAB antagonist in guinea-pig ileum[J]. British Journal of Pharmacology, 1983, 79 4: 855-862. DOI: 10.1111/j.1476-5381.1983.tb10529.x |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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