ChemicalBook--->CAS DataBase List--->83960-27-4

83960-27-4

83960-27-4 Structure

83960-27-4 Structure
IdentificationBack Directory
[Name]

N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY
[CAS]

83960-27-4
[Synonyms]

N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY
N-DANSYL-D-ALA-GLY-P-NITRO-PHE-GLY
Dansyl-D-Ala-Gly-4-nitro-Phe-Glu-OH
DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY-OH TRIFLUOROACETATE
Dansyl-D-Ala-Gly-4-nitro-Phe-Gly-OH trifluoroacetate salt
Glycine, N-[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]-D-alanylglycyl-4-nitro-L-phenylalanyl-
2-((S)-2-(2-((R)-2-(5-(diMethylaMino)naphthalene-1-sulfonaMido)propanaMido)acetaMido)-3-(4-nitrophenyl)propanaMido)acetic acid
[Molecular Formula]

C28H32N6O9S
[MDL Number]

MFCD00133590
[MOL File]

83960-27-4.mol
[Molecular Weight]

628.65
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

methanol: 50mg
[form ]

powder
[Sequence]

{Dansyl}-{d-Ala}-Gly-{Phe(pNO2)}-Gly
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Dansyl-D-Ala-Gly-Phe(pNO2)-Gly is a synthetic peptide substrate. As a substrate of NEP, Dansyl-D-Ala-Gly-Phe(pNO2)-Gly can be specifically recognized and cleaved by the enzyme, thereby releasing the fluorophore dansyl, which can be quantitatively detected. Therefore, it is often used to determine the activity of NEP[1].
[References]

[1] Niikura T, et al. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice[J]. PloS one, 2011, 6(1): e16259. DOI:10.1371/journal.pone.0016259
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