| Identification | Back Directory | [Name]
Gastric Mucin | [CAS]
84082-64-4 | [Synonyms]
MUCIN
Gastron
MUCIN TYPE I
MUCIN TYPE II
MUCIN GASTRIC
Gastric Mucin
Mutin(gastric)
MUCIN TYPE III
MUCIN TYPE I-S
Mucins, gastric
MUCIN,CRUDE,TYPEII
Mucin from porcine
MUCIN, GASTRIC, HOG
GASTRIC MUCIN PORCINE
Gastric Mucin USP/EP/BP
mucin from porcine stomach
EleMent of gastric Mucous MeMbrane
MUCIN FROM PORCINE STOMACH, TYPE III | [EINECS(EC#)]
282-010-7 | [Molecular Formula]
NULL | [MDL Number]
MFCD00131629 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C
| [solubility ]
1 M NaOH: soluble20mg/mL | [form ]
partially purified powder
| [color ]
Off-white to light yellow | [biological source]
Porcine stomach |
| Hazard Information | Back Directory | [Description]
Mucins are high-molecular-weight glycoproteins expressed throughout the gastrointestinal tract, with a key role in mucosal protection and function. In gastric cancer expression of MUC5AC and MUC1 is reduced and denovo expression of MUC2 occurs. | [Chemical Properties]
This product is a white to yellowish-white powder or yellowish-brown granules with a peptone-like odor and a salty taste. It is highly hygroscopic and swells in water. Its aqueous solution is gray or milky white. It does not precipitate when heated, but does precipitate when exposed to weak acids. It can be precipitated by 60% or more of ethanol or acetone. Prolonged exposure to acid can decompose it into various proteins and polysaccharides. | [Uses]
Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa. | [General Description]
Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus. It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli. | [Biological Activity]
Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin-17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients. | [Biochem/physiol Actions]
Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells. |
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