| Identification | Back Directory | [Name]
2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol | [CAS]
841253-81-4 | [Synonyms]
2-Piperidineethanol, 1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-
2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol | [Molecular Formula]
C20H23ClN4O | [MDL Number]
MFCD05710220 | [MOL File]
841253-81-4.mol | [Molecular Weight]
370.88 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to light brown | [InChI]
1S/C20H23ClN4O/c1-14-12-20(24-10-3-2-4-17(24)9-11-26)25-19(22-14)13-18(23-25)15-5-7-16(21)8-6-15/h5-8,12-13,17,26H,2-4,9-11H2,1H3 | [InChIKey]
TZWSGOPCLUTFBZ-UHFFFAOYSA-N | [SMILES]
ClC(C=C1)=CC=C1C2=NN(C(N3C(CCO)CCCC3)=CC(C)=N4)C4=C2 |
| Hazard Information | Back Directory | [Uses]
CMPPE is a GABAB receptor positive allosteric modulator (PAM) that inhibits alcohol self-administration and reinstatement behavior in rats[1]. | [Biological Activity]
CMPPE is a GABAB receptor positive allosteric modulator (PAM). GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to mudulate GABA release and regulate K+ channels and Ca++ channels. CMPPE has the highest hypoactivity/anticonvulsant ratio. | [References]
[1] Paola Maccioni, et al. Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats. Alcohol. 2019 Mar:75:79-87. DOI:10.1016/j.alcohol.2018.05.015 |
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