| Identification | Back Directory | [Name]
BITHIONOL SULFOXIDE | [CAS]
844-26-8 | [Synonyms]
bitins
sulphene
distobitin
disto-5-cogla
Bithionoloxide
BITHIONOL SULFOXIDE
LABOTEST-BB LT00772303
Bithionol sulfoxidewith
2,2’-sulfinylbis(4,6-dichloro-pheno
6,6’-sulfinylbis(2,4-dichlorophenol)
2,2'-SULFINYL-BIS-(4,6-DICHLOROPHENOL)
Phenol, 2,2'-sulfinylbis[4,6-dichloro-
2,2zzhlxy-Sulfinyl bis-4,6-dichlorophenol
2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol
2,4-dichloro-6-(3,5-dichloro-2-hydroxy-phenyl)sulfinyl-phenol | [EINECS(EC#)]
212-679-2 | [Molecular Formula]
C12H6Cl4O3S | [MDL Number]
MFCD00056677 | [MOL File]
844-26-8.mol | [Molecular Weight]
372.05 |
| Chemical Properties | Back Directory | [Melting point ]
220 °C(Solv: methanol (67-56-1)) | [Boiling point ]
532.7±50.0 °C(Predicted) | [density ]
1.86±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 250 mg/mL (671.95 mM) | [form ]
Solid | [pka]
4.79±0.48(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection[1][2][5]. | [in vivo]
Bithionol sulfoxide (oral administration) shows LD50 values of 1000-5000 mg/kg (mice) and about 5000 mg/kg (rats), and increased serum AST at high doses (5000-100 mg/kg)[3].
Bithionol sulfoxide (80 and 90 mg/kg, oral administration) is effective against natural rumen fluke infections in dairy cattle[4].
| Animal Model: | Dairy cattle[4] | | Dosage: | 60, 80 90 mg/kg | | Administration: | Oral administration | | Result: | Showed approximately 70% effective against rumen flukes infection at dosages of 80 and 90 mg/kg after one week post treatment. |
| [IC 50]
Schistosome | [storage]
Store at -20°C | [References]
[1] Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62. DOI:10.3354/dao02269
[2] S P Yang, et al. Treatment of paragonimiasis with bithionol and bithionol sulfoxide. Dis Chest. 1967 Aug;52(2):220-32. DOI:10.1378/chest.52.2.220
[3] Lavri? A, et al. Oral toxicity of bithionol sulfoxide in mice and rats. Zbornik Veterinarske Fakultete Univerza Ljubljana 1990 Vol.27 No.1 pp.33-39 ref.22.
[4] Chompoochan T, et al. The anthelmintic effects of bithionol sulfoxide against sheep experimentally infected with Fasciola gigantica[C]//ACIAR PROCEEDINGS. 1996: 189-194.
[5] D.Mourot, et al. Mutagenicity of bithionol sulfoxide and its metabolites in the Salmonella/mammalian microsome test. Mutation Research/Genetic Toxicology, 1987, 188(1): 53-55. |
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