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84449-90-1

84449-90-1 Structure

84449-90-1 Structure
IdentificationMore
[Name]

Raloxifene
[CAS]

84449-90-1
[Synonyms]

RALOXIFEN
RALOXIFENE
[4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methanone.HCL
[6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride
RALOXAFINE
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
[6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone hydrochloride
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-y1][4-[2-(1-piperidinyl)ethoxy]phenyl]methamone
Evista
Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl] ketone
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
2-(4-Hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene-6-ol
[Molecular Formula]

C28H27NO4S
[MDL Number]

MFCD00866415
[Molecular Weight]

473.58
[MOL File]

84449-90-1.mol
Chemical PropertiesBack Directory
[Appearance]

Light-Yellow Solid
[mp ]

250-253°C
[solubility ]

DMSO: 28 mg/mL, soluble
[form ]

solid
[color ]

light yellow
[Usage]

A nonsteroidal estrogen receptor mixed agonist/antagonist
[CAS DataBase Reference]

84449-90-1(CAS DataBase Reference)
Safety DataBack Directory
[WGK Germany ]

3
[HS Code ]

29349990
[Hazardous Substances Data]

84449-90-1(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Methanesulfonyl chloride-->Biphenyl-->Thianaphthene-->2-Bromo-4'-methoxyacetophenone-->Phenetole
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Raloxifene(84449-90-1).msds
Questions And AnswerBack Directory
[Application in Particular Diseases]

In Osteoporosis:
  • Raloxifene is an estrogen agonist on bone but an antagonist on the breast and uterus. It is approved for prevention and treatment of postmenopausal osteoporosis. Other estrogen agonists/antagonists may be approved soon (e.g., bazedoxifene, lasofoxifene).
  • Raloxifene decreases vertebral fractures and increases spine and hip BMD, but to a lesser extent than bisphosphonates. After discontinuation, the beneficial effect is lost and bone loss returns to age- or disease-related rates.
  • Raloxifene (like tamoxifen) is associated with decreased breast cancer risk. Raloxifene is associated with decreases in total and low-density lipoprotein cholesterol, neutral effects on high-density lipoprotein cholesterol, but slight increases in triglycerides; no beneficial cardiovascular effects have yet been demonstrated.
  • Raloxifene is well tolerated overall. Hot flushes occur more frequently in women recently finishing menopause or discontinuing estrogen therapy (ET). Endometrial bleeding occurs rarely. Raloxifene is contraindicated in women with an active or past history of venous thromboembolism. Therapy should be stopped if a patient anticipates extended immobility.
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

84449-90-1(sigmaaldrich)
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