| Identification | Back Directory | [Name]
Hydrazinecarboximidamide, 2-[[4-chloro-3-(trifluoromethyl)phenyl]methylene]-, hydrochloride (1:1) | [CAS]
849335-07-5 | [Synonyms]
Hydrazinecarboximidamide, 2-[[4-chloro-3-(trifluoromethyl)phenyl]methylene]-, hydrochloride (1:1) | [Molecular Formula]
C9H9Cl2F3N4 | [MOL File]
849335-07-5.mol | [Molecular Weight]
301.09 |
| Hazard Information | Back Directory | [Uses]
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2]. | [in vivo]
AC-099 hydrochloride (compound 3; 30 mg/kg; i.p.; single) completely attenuates spinal nerve ligation (SNL)-induced hypersensitivity in rats[2]. | Animal Model: | Male Sprague-Dawley rats (175-300g; spinal nerve ligation (SNL) model)[2]. | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection; single. | | Result: | Completely attenuated SNL-induced hypersensitivity. |
| [References]
[1] Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. DOI:10.1021/jm300535s
[2] Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4. DOI:10.1021/jm9011998 |
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|