| Hazard Information | Back Directory | [Definition]
ChEBI: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(4-propan-2-yl-1-piperazinyl)phenyl]methanone is an aromatic ketone. | [in vivo]
Y134 (1-3 mg/kg/day; p.o. for 3 days) abolishes the E2-induced mammary gland terminal end bud (TEB) outgrowth in ovariectomized rats. Y134 inhibits uterine cell proliferation induced by E2 in a dose-dependent manner[1]. | Animal Model: | Four-week old female Sprague-Dawley rats were received ovariectomy[1] | | Dosage: | 1, 3 mg/kg | | Administration: | P.o. daily for 3 days | | Result: | Abolished the effect exerted by E2 in a dose-dependent manner.
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| [IC 50]
ERα: 0.09 nM (Ki); ERβ: 11.31 nM (Ki) | [storage]
Desiccate at RT |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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