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Chemical PropertiesBack Directory
[solubility ]

Soluble to 100 mM in DMSO and to 100 mM in ethanol
[form ]

Powder
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Definition]

ChEBI: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(4-propan-2-yl-1-piperazinyl)phenyl]methanone is an aromatic ketone.
[in vivo]

Y134 (1-3 mg/kg/day; p.o. for 3 days) abolishes the E2-induced mammary gland terminal end bud (TEB) outgrowth in ovariectomized rats. Y134 inhibits uterine cell proliferation induced by E2 in a dose-dependent manner[1].

Animal Model:Four-week old female Sprague-Dawley rats were received ovariectomy[1]
Dosage:1, 3 mg/kg
Administration:P.o. daily for 3 days
Result:Abolished the effect exerted by E2 in a dose-dependent manner.
[IC 50]

ERα: 0.09 nM (Ki); ERβ: 11.31 nM (Ki)
[storage]

Desiccate at RT
Spectrum DetailBack Directory
[Spectrum Detail]

Y 134(849662-80-2)1HNMR
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