Identification | Back Directory | [Name]
2-Propenamide, N-[3-[2,6-dibromo-4-[2-(dimethylamino)ethyl]phenoxy]propyl]-3-[3,5-dibromo-4-[3-(dimethylamino)propoxy]phenyl]-, (2E)- | [CAS]
850013-02-4 | [Synonyms]
Psammaplysene A (E)-N-[3-[2,6-Dibromo-4-[2- (dimethylamino)ethyl]phenoxy]propyl]-3-[3,5-dibromo-4- [3-(dimethylamino)propoxy]phenyl]prop-2-enamide 2-Propenamide, N-[3-[2,6-dibromo-4-[2-(dimethylamino)ethyl]phenoxy]propyl]-3-[3,5-dibromo-4-[3-(dimethylamino)propoxy]phenyl]-, (2E)- | [Molecular Formula]
C27H35Br4N3O3 | [MOL File]
850013-02-4.mol | [Molecular Weight]
769.2 |
Chemical Properties | Back Directory | [Boiling point ]
762.0±60.0 °C(Predicted) | [density ]
1.571±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.84±0.46(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Description]
Psammaplysene A is a naturally occurring inhibitor of FOXO1a nuclear export. | [Uses]
Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research[1]. | [References]
[1] Emily Berry, et al. Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1. Gynecol Oncol. 2009 Feb;112(2):331-6. |
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