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851095-32-4

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851095-32-4 Structure

851095-32-4 Structure
IdentificationBack Directory
[Name]

STX-0119
[CAS]

851095-32-4
[Synonyms]

STX-0119
4-Quinolinecarboxamide, N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-2-phenyl-
[Molecular Formula]

C22H14N4O3
[MDL Number]

MFCD04462306
[MOL File]

851095-32-4.mol
[Molecular Weight]

382.37
Chemical PropertiesBack Directory
[density ]

1.374±0.06 g/cm3(Predicted)
[storage temp. ]

4°C, protect from light
[solubility ]

DMSO: soluble
[form ]

Solid
[pka]

9.26±0.70(Predicted)
[color ]

White to light yellow
[InChIKey]

MNPXTRXFUMGQLK-UHFFFAOYSA-N
[SMILES]

O=C(NC1=NN=C(C2=CC=CO2)O1)C3=CC(C4=CC=CC=C4)=NC5=C3C=CC=C5
Safety DataBack Directory
[WGK Germany ]

WGK 2
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-2-phenyl-4-quinolinecarboxamide is a small molecular inhibitor of STAT3, a cancer therapeutic agent against Glioblastoma multiforme tumor cells, and a drug target.
[in vivo]

STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice[1].
The plasma concentration of STX-0119 (160 mg/kg; oral gavage) is maintained at >100 μg/mL (>260 μM), even at 8 h after administration[1].

Animal Model:Male BALB/cA-ν/ν nude mice, SCC-3 lymphoma xenograft model[1]
Dosage:160 mg/kg
Administration:Oral gavage, daily for 4 days
Result:Suppressed the growth of SCC-3 cells significantly on the fourth day.
[IC 50]

STAT3: 74 μM (IC50, STAT3 transcription)
Spectrum DetailBack Directory
[Spectrum Detail]

STX-0119(851095-32-4)1HNMR
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