| Identification | Back Directory | [Name]
Pyrazolo[3,4-d]azepine, 3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydro-1-(phenylmethyl)- | [CAS]
851373-91-6 | [Synonyms]
Morantel Impurity 6
Pyrazolo[3,4-d]azepine, 3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydro-1-(phenylmethyl)- | [Molecular Formula]
C20H20ClN3 | [MOL File]
851373-91-6.mol | [Molecular Weight]
337.85 |
| Hazard Information | Back Directory | [Uses]
JNJ-18038683 free base is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. | [References]
[1] Bonaventure P, et al. Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder. J Pharmacol Exp Ther. 2012 Aug;342(2):429-40. DOI:10.1124/jpet.112.193995 |
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