| Identification | Back Directory | [Name]
15-DEOXY-DELTA12,14-PROSTAGLANDIN D2 | [CAS]
85235-11-6 | [Synonyms]
QUGBPWLPAUHDTI-PLGLXCLHSA-N
15-deoxy-Δ12,14-Prostaglandin D2
15-DEOXY-DELTA12,14-PROSTAGLANDIN D2
9ALPHA,HYDROXY-11-OXO-PROSTA-5Z,12E,14E-TRIEN-1-OIC ACID | [Molecular Formula]
C20H30O4 | [MDL Number]
MFCD00797638 | [MOL File]
85235-11-6.mol | [Molecular Weight]
334.45 |
| Chemical Properties | Back Directory | [Boiling point ]
535.0±50.0 °C(Predicted) | [density ]
1.113±0.06 g/cm3(Predicted) | [solubility ]
DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >5 mg/ml (from PGD2) | [form ]
Liquid | [pka]
4.75±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 . It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM. 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 μg/ml). It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2. | [Uses]
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation (EC50=8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/ml) and inhibits ADP-induced platelet aggregation (IC50=320 ng/mL). | [References]
[1] Bundy, et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J. Med. Chem. 26(6), 790-799 (1983). |
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