| Identification | Back Directory | [Name]
N-[(4-fluorophenyl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine | [CAS]
852407-49-9 | [Synonyms]
WAY-354890
N-(4-Fluorobenzyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine
N-(4-fluorobenzyl)-N-(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)amine
N-[(4-fluorophenyl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine
[1]Benzothieno[2,3-d]pyrimidin-4-amine, N-[(4-fluorophenyl)methyl]-5,6,7,8-tetrahydro- | [Molecular Formula]
C17H16FN3S | [MDL Number]
MFCD04589967 | [MOL File]
852407-49-9.mol | [Molecular Weight]
313.39 |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-145 (compound 7c) is an EGFR kinase inhibitor. At a concentration of 20 μM, EGFR-IN-145 has an inhibition rate of 52.7% on EGFR-wild type kinase[1]. | [References]
[1] Wu CH, et al. Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency. J Med Chem. 2010 Oct 28;53(20):7316-26. DOI:10.1021/jm100607r |
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| Company Name: |
OTAVA chemicals
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| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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