| Identification | Back Directory | [Name]
N,N-Dimethyl-2-((3-phenyl-2-quinolinyl)thio)ethanamine monohydrochloride | [CAS]
85273-96-7 | [Synonyms]
CI 169369
2-(2-Dimethylaminoethylthio)-3-phenylquinoline hydrochloride
N,N-Dimethyl-2-((3-phenyl-2-quinolinyl)thio)ethanamine monohydrochloride
Ethanamine, N,N-dimethyl-2-((3-phenyl-2-quinolinyl)thio)-, monohydrochloride | [Molecular Formula]
C19H21ClN2S | [MOL File]
85273-96-7.mol | [Molecular Weight]
344.901 |
| Hazard Information | Back Directory | [Uses]
ICI 169369 is an orally active, specific serotonin and 5-HT2/5-HT1C receptor competitive antagonist. ICI 169369 exhibits Ki values of 1.79 x 10?8 and 1.58 x 10?6 M for 5-HT2 and 5-HT1, respectively[1][2]. | [References]
[1] D S Millson, et al. The effects of a 5-HT2 receptor antagonist (ICI 169,369) on changes in waking EEG, pupillary responses and state of arousal in human volunteers. Br J Clin Pharmacol. 1991 Oct;32(4):447-54. DOI:10.1111/j.1365-2125.1991.tb03929.x
[2] T P Blackburn, et al. In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist. Eur J Pharmacol. 1988 Jun 10;150(3):247-56. DOI:10.1016/0014-2999(88)90005-2 |
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