| Identification | Back Directory | [Name]
RF-489791 | [CAS]
853003-48-2 | [Synonyms]
RF-489791
PF00489791
PF-00489791
PF 00489791
1-(2-ethoxyethyl)-5-[ethyl(methyl)amino]-7-[(4-methylpyridin-2-yl)amino]-N-methylsulfonylpyrazolo[4,3-d]pyrimidine-3-carboxamide
1-(2-Ethoxyethyl)-5-(ethyl(methyl)amino)-7-((4-methylpyridin-2-yl)amino)-N-(methylsulfonyl)-1H-pyrazolo[4,3-d]pyrimidine-3-carboxamide | [Molecular Formula]
C20H28N8O4S | [MDL Number]
MFCD18782748 | [MOL File]
853003-48-2.mol | [Molecular Weight]
476.553 |
| Chemical Properties | Back Directory | [solubility ]
Acetonitrile: Soluble
DMF: Slightly soluble
DMSO: Slightly soluble
Water: Soluble | [form ]
Solid | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC50 of 1.5 nM. PF-00489791 can enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function[1]. | [IC 50]
PDE5A: 5 nM (IC50) | [References]
[1] Frank S Menniti, et al. A non-brain penetrant PDE5A inhibitor improves functional recovery after stroke in rats. Restor Neurol Neurosci. 2012;30(4):283-9. DOI:10.3233/RNN-2012-110187 |
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