853003-48-2

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853003-48-2 Structure

Identification	Back Directory
[Name] RF-489791
[CAS] 853003-48-2
[Synonyms] RF-489791 PF00489791 PF-00489791 PF 00489791 1-(2-ethoxyethyl)-5-[ethyl(methyl)amino]-7-[(4-methylpyridin-2-yl)amino]-N-methylsulfonylpyrazolo[4,3-d]pyrimidine-3-carboxamide 1-(2-Ethoxyethyl)-5-(ethyl(methyl)amino)-7-((4-methylpyridin-2-yl)amino)-N-(methylsulfonyl)-1H-pyrazolo[4,3-d]pyrimidine-3-carboxamide
[Molecular Formula] C20H28N8O4S
[MDL Number] MFCD18782748
[MOL File] 853003-48-2.mol
[Molecular Weight] 476.553

Chemical Properties	Back Directory
[form ] Solid
[color ] Light yellow to green yellow

Hazard Information	Back Directory
[Uses] PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC50 of 1.5 nM. PF-00489791 can enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function[1].
[IC 50] PDE5A: 5 nM (IC₅₀)
[References] [1] Frank S Menniti, et al. A non-brain penetrant PDE5A inhibitor improves functional recovery after stroke in rats. Restor Neurol Neurosci. 2012;30(4):283-9. DOI:10.3233/RNN-2012-110187

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