| Identification | Back Directory | [Name]
S- (+)-Rolipram | [CAS]
85416-73-5 | [Synonyms]
(+)-Rolipram
(S)-(+)-ROLIPRAM
Rolipram (S)-(+)-
S- (+)-Rolipram (ME-3167
S- (+)-Rolipram USP/EP/BP
(+)-ROLIPRAM;(S)-ROLIPRAM
(4S)-4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone
(4S)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
(S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
(4S)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
(4S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one
(S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)- | [Molecular Formula]
C16H21NO3 | [MDL Number]
MFCD03093861 | [MOL File]
85416-73-5.mol | [Molecular Weight]
275.34 |
| Chemical Properties | Back Directory | [Melting point ]
133-136℃ | [density ]
1.155 | [storage temp. ]
Store at RT | [solubility ]
DMSO : 100 mg/mL (363.19 mM; Need ultrasonic) | [form ]
White to off-white solid. | [color ]
White to Almost white |
| Hazard Information | Back Directory | [Uses]
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer | [Definition]
ChEBI: The (S)-enantiomer of rolipram. | [Biological Activity]
Less active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ). | [storage]
Room temperature |
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