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85416-73-5

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85416-73-5 Structure

85416-73-5 Structure
IdentificationBack Directory
[Name]

S- (+)-Rolipram
[CAS]

85416-73-5
[Synonyms]

(+)-Rolipram
(S)-(+)-ROLIPRAM
Rolipram (S)-(+)-
S- (+)-Rolipram (ME-3167
S- (+)-Rolipram USP/EP/BP
(+)-ROLIPRAM;(S)-ROLIPRAM
(4S)-4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone
(4S)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
(S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
(4S)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
(4S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one
(S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)-
[Molecular Formula]

C16H21NO3
[MDL Number]

MFCD03093861
[MOL File]

85416-73-5.mol
[Molecular Weight]

275.34
Chemical PropertiesBack Directory
[Melting point ]

133-136℃
[density ]

1.155
[storage temp. ]

Store at RT
[solubility ]

DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
[form ]

White to off-white solid.
[color ]

White to Almost white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[HS Code ]

2933.79.1500
Hazard InformationBack Directory
[Uses]

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer
[Definition]

ChEBI: The (S)-enantiomer of rolipram.
[Biological Activity]

Less active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ).
[in vivo]

(+)-Rolipram (0.025-6.25 mg/kg; a single i.p.) dose-dependently inhibits locomotor activity and induces head twitches in rats[2].
(+)-Rolipram (0.06-25 mg/kg; a single i.p.) causes a dose-related fall in rectal temperature of rats[2].

[IC 50]

PDE4: 1100 nM (IC50)
[storage]

Room temperature
Spectrum DetailBack Directory
[Spectrum Detail]

S- (+)-Rolipram(85416-73-5)1HNMR
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