| Identification | Back Directory | [Name]
U-63557A | [CAS]
85666-17-7 | [Synonyms]
U-63557A
FUREGRELATE SODIUM
SODIUM FUREGRELATE
furegralate sodium
FUREGRELATE SODIUM SALT
Furegrelate Sodium (U-63557A)
Sodium 5-(3-pyridinylmethyl)-2-benzofurancarboxylate
5-(3'-Pyridinylmethyl)benzofuran-2-carboxylate sodium
sodium:5-(pyridin-3-ylmethyl)-1-benzofuran-2-carboxylate
5-(3-Pyridylmethyl)benzofuran-2-carboxylic acid sodium salt
5-[3,PYRIDINYLMETHYL]BENZO-FURAN-CARBOXYLIC ACID SODIUM SALT
5-(3-PYRIDINYLMETHYL)-2-BENZOFURANCARBOXYLIC ACID, SODIUM SALT
2-Benzofurancarboxylic acid, 5-(3-pyridinylmethyl)-, sodium salt
5-(3-Pyridinylmethyl)benzofurancarboxylic acid sodium-potassium salt | [Molecular Formula]
C15H10NNaO3 | [MDL Number]
MFCD00058448 | [MOL File]
85666-17-7.mol | [Molecular Weight]
275.23 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
DMF: >25 mg/ml; DMSO: >21 mg/ml; Ethanol: >14.5 mg/ml; PBS pH 7.2: >16.5 mg/ml | [form ]
White to off-white crystalline solid. | [color ]
White to light yellow | [Water Solubility ]
Soluble in water at approximately 15mg/ml |
| Hazard Information | Back Directory | [Uses]
Inhibitor (thromboxane synthetase). | [in vivo]
Furegrelate Sodium (1-5 mg/kg; po) prevents blockage of the coronary artery[1].
Furegrelate Sodium (0.1-5 mg/kg; i.v.) prevents the blockage of stenosed coronary arteries caused platelet aggregation[1].
Furegrelate Sodium blunts the development of hypoxia-induced pulmonary arterial hypertension (PAH) in an established neonatal piglet model primarily by preserving the structural integrity of the pulmonary vasculature[2].
Furegrelate has a long half-life compared to several other drugs used to treat PAH, including nitric oxide and prostagcyclin analogues; And Furegrelate is highly specific to the target enzyme[2]. | Animal Model: | Mongrel dogs (19-30 kg)[1] | | Dosage: | 1-5 mg/kg | | Administration: | Oral (via a gastric tube) | | Result: | Prevented blockage of the coronary artery. |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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