| Identification | Back Directory | [Name]
1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)- | [CAS]
856691-44-6 | [Synonyms]
1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)- | [Molecular Formula]
C30H35NO7 | [MOL File]
856691-44-6.mol | [Molecular Weight]
521.6 |
| Chemical Properties | Back Directory | [Boiling point ]
725.5±60.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 190 mg/mL (364.26 mM; Need ultrasonic) | [form ]
Solid | [pka]
4.25±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM[1]. | [Biological Activity]
ONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM[1].
VT107 (0.1~10000 μM; LPA1-B103 and Vector-B103 cells) results in inhibition of Ca2+ mobilization[1].ONO-9780307 is used to solve the LPA1 crystal structure, binds to an orthosteric site in LPA1[1]. | [IC 50]
LPA1 Receptor: 2.7 nM (IC50) | [storage]
4°C, protect from light | [References]
[1]. Mizuno H, et al. Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry. J Lipid Res. 2019;60(1):212-217. |
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