| Identification | Back Directory | [Name]
INOSINATE5'-DIPHOSPHATE | [CAS]
86-04-4 | [Synonyms]
5'-IDP
Riboxin
Inosine Diphosphate
Inosine pyrophosphate
Inosine 5'-diphosphoric acid
Inosine-5''-disphosporic acid
inosine 5'-(trihydrogen diphosphate)
[[(2R,3R,4R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid | [EINECS(EC#)]
201-648-9 | [Molecular Formula]
C10H14N4O11P2 | [MOL File]
86-04-4.mol | [Molecular Weight]
428.19 |
| Hazard Information | Back Directory | [Uses]
Riboxin (IDP), an orally active purine derivative-hypoxanthine rlboside, has antihypoxic and antihyperthermic activity. Riboxin also has an antiarrhythmic action in cats, rabbits, and mice with cardiac rhythm disorders induced by Ouabain. Riboxin protects animals against the noxious effects of γ-irradiation[1][2]. | [Definition]
ChEBI: A purine ribonucleoside 5'-diphosphate having inosine as the nucleobase. | [in vivo]
Riboxin (250 mg/kg; p.o.; single dose) increases the swimming duration of the mice, with no significant influence on the strength endurance. At the same condition, Riboxin increases the rate of survival of the experimental animals in the thermal chamber[1].
Riboxin (50 mg/kg; p.o.; once daily for 6 days) increases the hanging duration of the mice, while has no significant effect on the duration of swimming and running[1].
Riboxin (100 mg/kg; p.o.; 1 h befor test) has appreciable radio protective effect against γ-irradiation for mice[1].
| [References]
[1] Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14(1): 34-39.
[2] Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24. |
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