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863971-12-4

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863971-12-4 Structure

863971-12-4 Structure
IdentificationBack Directory
[Name]

MMAF-OMe
[CAS]

863971-12-4
[Synonyms]

MMAF-OMe
MONOMETHYL AURISTATIN F METHYL ESTER
ADC Payload,Inhibitor,MMAF-OMe,inhibit,MMAFOMe,MMAF OMe,ADC Cytotoxin
L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester
[Molecular Formula]

C40H67N5O8
[MDL Number]

MFCD30535529
[MOL File]

863971-12-4.mol
[Molecular Weight]

746
Chemical PropertiesBack Directory
[Boiling point ]

871.8±65.0 °C(Predicted)
[density ]

1.095±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

13.89±0.46(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.
[IC 50]

Auristatin
[References]

[1] Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300 DOI:10.1158/1535-7163.MCT-15-0881
Spectrum DetailBack Directory
[Spectrum Detail]

MMAF-OMe(863971-12-4)1HNMR
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