| Identification | Back Directory | [Name]
Succinyl phosphonate trisodium salt | [CAS]
864167-45-3 | [Synonyms]
Succinyl phosphonate trisodium salt | [Molecular Formula]
C4H8NaO6P | [MDL Number]
MFCD32197250 | [MOL File]
864167-45-3.mol | [Molecular Weight]
206.07 |
| Hazard Information | Back Directory | [Uses]
Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3]. | [in vivo]
Succinyl phosphonate trisodium salt (0.02 mmol/kg, nasal administration) inhibits 2-oxogglutarate dehydrogenase in rats to reduce the low valley tathione redoxic state, and increases anxiety and interfered with stress adaption[5].
| [References]
[1] Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70. DOI:10.1016/0014-5793(96)00166-4
[2] Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21. DOI:10.18632/oncotarget.8387
[3] Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6. DOI:10.1016/j.neuroscience.2008.10.015
[4] Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61. DOI:10.1021/bi0503100
[5] Artiukhov AV, et al. Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation. Pharmaceuticals (Basel). 2022 Jan 31;15(2):182. DOI:10.3390/ph15020182 |
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