| Identification | Back Directory | [Name]
Mildronate dihydrate | [CAS]
86426-17-7 | [Synonyms]
Meldonium
Meldonium dihydrate
Mildronatedehydrate
Miridazine dihydrate
Mildronate dihydrate
Mildronate (hydrate)
Phosphonate dihydrate
Meldonium dihydrate CRS
Mildronate dihydrate, >=99%
Mildronate dihydrate USP/EP/BP
3-(2,2,2-Trimethylhydrazinium)propionate dihydrate
3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate dihydrate
Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt | [EINECS(EC#)]
695-494-3 | [Molecular Formula]
C6H14N2O2.2H2O | [MDL Number]
MFCD00876389 | [MOL File]
86426-17-7.mol | [Molecular Weight]
182.218 |
| Chemical Properties | Back Directory | [Melting point ]
85 - 87°C | [storage temp. ]
2-8°C | [solubility ]
H2O: >40mg/mL | [form ]
powder | [color ]
white to off-white | [Water Solubility ]
H2O: >40mg/mL | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C6H14N2O2.2H2O/c1-8(2,3)7-5-4-6(9)10;;/h7H,4-5H2,1-3H3;2*1H2 | [InChIKey]
JFWLFLLRLZSBRA-UHFFFAOYSA-N | [SMILES]
[N+](C)(C)(C)NCCC([O-])=O.O.O |
| Hazard Information | Back Directory | [Description]
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively. | [Uses]
Meldonium dihydrate has been used as an anti-ischemic agent to evaluate its protective effects on Ischemia-reperfusion (I/R) in chick embryos. | [Biochem/physiol Actions]
Meldonium is an Inhibitor of γ-butyrobetaine hydroxylase (BBOX) a key enzyme in the synthesis of carnitine. | [in vivo]
Meldonium (50, 100, or 200 mg/kg; once daily for 3 days) dihydrate modestly attenuates hypoxia-induced lung injury in mice[3]. | [storage]
Store at 2-8°C |
|
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Sigma-Aldrich
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