| Identification | Back Directory | [Name]
1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride | [CAS]
866396-70-5 | [Synonyms]
| [Molecular Formula]
C14H21ClN4O2 | [MOL File]
866396-70-5.mol | [Molecular Weight]
312.795 |
| Hazard Information | Back Directory | [Description]
DPPI 1c is an inhibitor of dipeptidyl peptidase 4. It decreased plasma glucose levels by 46 to 67% in an oral glucose challenge in fasted, diabetic KK/H1J mice when administered at doses ranging from 0.3 to 5 mg/kg. | [in vitro]
1-({[1-(Hydroxymethyl)cyclopentyl]amino}acetyl)pyrrolidine-2,5-cis-dicarbonitrile (1c) is an achiral, slow-binding (time-dependent) inhibitor of DPP-IV that is selective for DPP-IV over other DPP isozymes and proline specific serine proteases, and which has oral bioavailability in preclinical species and in vivo efficacy in animal models._x000D_
_x000D_
Reference: J Med Chem. 2006 Jun 1;49(11):3068-76. https://pubmed.ncbi.nlm.nih.gov/16722626/ | [in vivo]
1-({[1-(Hydroxymethyl)cyclopentyl]amino}acetyl)pyrrolidine-2,5-cis-dicarbonitrile (1c) is an achiral, slow-binding (time-dependent) inhibitor of DPP-IV that is selective for DPP-IV over other DPP isozymes and proline specific serine proteases, and which has oral bioavailability in preclinical species and in vivo efficacy in animal models._x000D_
_x000D_
Reference: J Med Chem. 2006 Jun 1;49(11):3068-76. https://pubmed.ncbi.nlm.nih.gov/16722626/ | [target]
A DPP-4 inhibitor. | [storage]
Desiccate at RT |
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