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866924-39-2

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866924-39-2 Structure

866924-39-2 Structure
IdentificationBack Directory
[Name]

Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester
[CAS]

866924-39-2
[Synonyms]

GW280264X，Carbamic acid
Benzyl ((S)-5-((2R,3S)-3-(N-hydroxyformamido)-2-isobutylhexanamido)-6-oxo-6-(thiazol-2-ylamino)hexyl)carbamate
Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester
[Molecular Formula]

C28H41N5O6S
[MDL Number]

MFCD33023416
[MOL File]

866924-39-2.mol
[Molecular Weight]

575.72
Chemical PropertiesBack Directory
[density ]

1.229±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

DMSO: soluble
[form ]

A crystalline solid
[pka]

8.27±0.50(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
Hazard InformationBack Directory
[Uses]

GW 280264X is a inhibitor of the metalloproteinase ADAM17.
[in vivo]

Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI)[3].

Animal Model:C57BL/6 mice[3]
Dosage:100 ?μg/kg
Administration:I.p. injected; every day for one week starting 4?h post-surgery
Result:Showed significantly improved functional recovery compared to the control group.
[IC 50]

ADAM17: 8 nM (IC50); ADAM10: 11.5 nM (IC50)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester(866924-39-2)1HNMR
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