| Identification | Back Directory | [Name]
Pre-queuosine1 dihydrochloride | [CAS]
86694-45-3 | [Synonyms]
PreQ1
preQ1 2HCl
PreQ1 dihydrochloride
Pre-queuosine1 dihydrochloride
PreQ1 dihydrochloride >=98% (HPLC)
7-Aminomethyl-7-deazaguanine dihydrochloride
2-Amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4(3H)-one
2-Amino-5-(aminomethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one dihydrochloride | [Molecular Formula]
C7H11Cl2N5O | [MOL File]
86694-45-3.mol | [Molecular Weight]
252.101 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to light brown | [InChIKey]
WUMBRQKOLVTYTB-UHFFFAOYSA-N | [SMILES]
Cl.Cl.[nH]1c2nc([nH][c](c2c(c1)CN)=O)N |
| Hazard Information | Back Directory | [Uses]
preQ1 dihydrochloride is a modified, guanine-derived nucleobase and a precursor of Queuine (HY-N10574) biosynthesis. preQ1 dihydrochloride binds to the aptamer of PreQ1 riboswitch with high affinity[1]. | [Biochem/physiol Actions]
PreQ1 (pre-queuosine1) is an intermediate of the queuosine pathway. Also, PreQ1 binds with high affinity to the aptamer of PreQ1 riboswitch, which attenuates protein expression. | [References]
[1] Connelly CM, et al. Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat Commun. 2019 Apr 2;10(1):1501. DOI:10.1038/s41467-019-09493-3 |
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