| Identification | Back Directory | [Name]
Benzyl-PEG5-Amine | [CAS]
86770-77-6 | [Synonyms]
Bn-P5-NH2
CAS_86770-77-6
Benzyl-PEG5-NH2
Benzyl-PEG5-Amine
H2N-(CH2CH2O)5-Bn
BnO-PEG4-CH2CH2NH2
1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-amine
2,5,8,11,14-Pentaoxahexadecan-16-amine, 1-phenyl-
2-(2-{2-[2-(2-Benzyloxy-ethoxy)- ethoxy]-ethoxy}-ethoxy)- ethylamine | [Molecular Formula]
C17H29NO5 | [MDL Number]
MFCD28976656 | [MOL File]
86770-77-6.mol | [Molecular Weight]
327.42 |
| Hazard Information | Back Directory | [Description]
Benzyl-PEG5-amine is a PEG linker containing a benzyl protecting group and a free terminal amine. Benzyl groups are used to protect alcohol moieties and can be removed via hydrogenolysis. The primary amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. The hydrophilic PEG linkers increase the water solubility of a compound in aqueous media. | [Uses]
Benzyl-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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