Identification | Back Directory | [Name]
MK-2048 | [CAS]
869901-69-9 | [Synonyms]
CS-1529 MK-2048 USP/EP/BP (S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-diMethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxaMide (6S)-2-[(3-Chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxopyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide Pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, 2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxo-, (6S)- | [Molecular Formula]
C22H24FN5O4 | [MOL File]
869901-69-9.mol | [Molecular Weight]
441.455 |
Hazard Information | Back Directory | [Uses]
MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with
resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV
enzyme integrase than the first generation inhibitor, raltegravir. | [target]
subtype B integrase |
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Company Name: |
NCE Biomedical Co.,Ltd.
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Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0.htm |
Company Name: |
SPIRO PHARMA
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Tel: |
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Website: |
www.spiropharma.com.cn |
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